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Exploring the Influence of Testosterone on Pain Perception and Modulation Among Men with Low and Normal Testosterone

Matthieu Vincenot1,2, Martine Bordeleau1,2, Flore le Blanc1,2

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Men with low testosterone levels exhibit heightened pain sensitivity. Testosterone may play a role in pain modulation and contribute to sex-based differences in pain perception.

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Pain Research

Background:

  • Individual pain perception varies significantly, with sex differences playing a role.
  • Sex hormones, particularly testosterone, are implicated in pain modulation.
  • The precise mechanisms by which testosterone influences pain remain unclear.

Purpose of the Study:

  • To investigate the influence of free testosterone levels on pain perception in men.
  • To examine how testosterone variations affect pain modulation mechanisms.

Main Methods:

  • Cross-sectional study involving 12 men with low testosterone and 16 controls.
  • Pain sensitivity assessed using heat pain threshold (HPT) and heat pain tolerance (HPTol).
  • Pain modulation evaluated via conditioned pain modulation (CPM) and temporal summation of pain (TSP).

Main Results:

  • Men with low testosterone had significantly lower heat pain threshold and tolerance compared to controls (p=0.02).
  • Free testosterone levels positively correlated with heat pain tolerance (r=0.40, p=0.03).
  • No significant differences were found in CPM or TSP responses between groups.

Conclusions:

  • Lower testosterone levels are associated with increased pain sensitivity in men.
  • Testosterone appears to have an antinociceptive effect.
  • These findings suggest testosterone may contribute to sex differences in pain perception.