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Epilepsy Treatment Outcome and Associated Factors in Children and Adolescents in a Resource-limited Setting: A

Mulugeta Sitot Shibeshi1, Kefyalew Taye Gari1

  • 1Department of Pediatrics and Child Health, College of Medicine and Health Sciences, Hawassa University, Ethiopia.

Clinical Medicine Insights. Pediatrics
|April 2, 2026
PubMed

Insights

Epilepsy treatment outcomes are poor for many children in low-resource settings. Factors like comorbidities and poor adherence contribute to poor seizure control, necessitating improved medication access and adherence support.

Area of Science:

  • Neurology
  • Pediatrics
  • Public Health

Background:

  • Epilepsy management in resource-limited settings presents significant challenges to achieving seizure control.
  • Effective treatment outcomes are crucial for the well-being of children and adolescents with epilepsy.

Purpose of the Study:

  • To evaluate treatment outcomes in pediatric epilepsy patients.
  • To identify factors associated with seizure control in children and adolescents with epilepsy.

Main Methods:

  • A retrospective cohort study of 270 pediatric patients (2-18 years) with epilepsy in southern Ethiopia.
  • Data collection involved patient/parent interviews and medical record reviews.
  • Logistic regression analysis identified factors linked to seizure control.

Main Results:

  • 55.2% of participants achieved complete seizure freedom for at least two years; 20% had reduced seizure frequency.
  • Poor seizure control was associated with neuropsychiatric comorbidities, delayed treatment response, polytherapy, and non-adherence.
  • Male gender and younger age (<10 years) were prevalent in the study cohort.

Conclusions:

  • A significant proportion of children and adolescents with epilepsy experience suboptimal treatment outcomes.
  • Addressing modifiable factors such as medication availability and treatment adherence is critical.
  • Stakeholder intervention is needed to improve epilepsy care and outcomes in resource-poor environments.
Abstract

Keywords:
Ethiopiaadolescentschildrenepilepsytreatment outcome

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