Related Experiment Video
Updated: Jul 26, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Case Report: MIS-C precipitating DKA and renal failure in a morbidly obese male with type 2 diabetes mellitus
John Tumberger1,2, Vincent Czerwinski1,2, Francesca Pérez Marquès1,2
1Division of Pediatric Critical Care, University of Kansas Medical Center, Kansas City, KS, United States.
Abstract:
Multisystem inflammatory syndrome in children (MIS-C) is a recently described systemic inflammatory sequelae of SARS-CoV-2 infection. Diagnostic criteria for MIS-C includes age <21, fever (>38°C), laboratory evidence of inflammation, clinically severe illness requiring hospitalization with multisystem (≥2) organ involvement, Evidence of current or recent SARS-CoV-2 infection or exposure, and has no alternative explanation for their symptoms. We present a 15-year-old, morbidly obese male whose diagnosis of MIS-C was obfuscated by diabetic ketoacidosis (DKA). This case highlights the increased risk of development of MIS-C in obese children, variability of presentation, and contributes to the body of research demonstrating endocrinologic complications of MIS-C.
Related Concept Videos
Diabetes Mellitus: Type 2 and Gestational
Type I Diabetes III: Clinical Manifestations
Complications of Diabetes Mellitus
Diabetic Ketoacidosis l: Introduction
Diabetic Ketoacidosis ll: Pathophysiology
Diabetic Nephropathy

