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Related Concept Videos

Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Infertility in Females01:28

Infertility in Females

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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
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Related Experiment Video

Updated: Apr 3, 2026

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
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Family Planning in Neuroinflammatory Disease.

Ruth Dobson, Kerstin Hellwig

    Continuum (Minneapolis, Minn.)
    |April 2, 2026
    PubMed
    Summary

    Family planning is crucial for individuals with neuroinflammatory disorders considering pregnancy. Modern treatments allow safe pregnancy and breastfeeding while managing disease effectively.

    Area of Science:

    • Neurology
    • Immunology
    • Reproductive Medicine

    Background:

    • Neuroinflammatory disorders require careful management during family planning and pregnancy.
    • Treatment withdrawal for pregnancy can increase relapse risk in conditions like multiple sclerosis.

    Purpose of the Study:

    • To provide evidence-based guidance for family planning in neuroinflammatory disorders.
    • To optimize treatment selection for balancing disease control and pregnancy outcomes.

    Main Methods:

    • Review of current treatment paradigms for neuroinflammatory diseases around pregnancy.
    • Analysis of safety data for immunomodulatory therapies during pregnancy and breastfeeding.

    Main Results:

    • CD20-antibody and induction therapies can suppress relapse rates during pregnancy.

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  • Monoclonal antibodies show promise for safety during pregnancy and breastfeeding in multiple sclerosis, NMOSD, and MOGAD.
  • Eculizumab and interleukin-6 antibodies offer additional options for NMOSD and MOGAD.

    • Conclusions:

    • Modern treatments enable safe pregnancies and breastfeeding in women with neuroinflammatory diseases.
    • Early and continuous family planning is essential for effective disease management and optimal outcomes.
    • Shared decision-making is key to balancing disease control with reproductive health.