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Related Concept Videos

Esophagus01:24

Esophagus

4.7K
The esophagus, a muscular conduit linking the pharynx and stomach, measures roughly 10 inches (25.4 cm) and sits behind the trachea. It remains collapsed when not swallowing. The esophagus follows a predominantly straight path through the thoracic mediastinum and enters the abdominal cavity through a diaphragmatic opening known as the esophageal hiatus.
The movement of edibles from the pharynx into the esophagus is facilitated by the upper esophageal sphincter, which is formed primarily by the...
4.7K
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

1.5K
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
1.5K
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

918
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
918
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

1.2K
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
1.2K
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

1.3K
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
1.3K
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

1.1K
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
1.1K

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  3. Esophagus Bioengineering.
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  3. Esophagus Bioengineering.

Related Experiment Video

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats
08:56

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats

Published on: February 10, 2020

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Esophagus Bioengineering.

Marta Gazzaneo1,2, Soichi Shibuya1,3, Natalie Durkin1

  • 1Stem Cell and Regenerative Medicine Section, Developmental Biology and Cancer Research and Teaching Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.

European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [Et Al] = Zeitschrift Fur Kinderchirurgie
|April 2, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Tissue engineering offers hope for esophageal disorders, but full-thickness defect repair remains challenging. Further research is needed for standardized, reproducible esophageal replacement strategies.

More Related Videos

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
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Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

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Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model
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Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model

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Related Experiment Videos

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats
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Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
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Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model
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Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Gastroenterology

Background:

  • Esophageal disorders often require innovative treatments beyond conventional therapies.
  • Current tissue engineering approaches utilize scaffolds and cell-based therapies for esophageal regeneration.
  • Hybrid strategies combining exogenous cell delivery show promise for enhanced outcomes and modulated inflammation.

Purpose of the Study:

  • To review current tissue engineering strategies for esophageal atresia.
  • To critically evaluate existing evidence in esophageal tissue engineering.
  • To discuss future research directions for esophageal replacement.

Main Methods:

  • Literature review of tissue engineering strategies for esophageal disorders.
  • Critical analysis of preclinical and clinical data.
  • Synthesis of current evidence and identification of research gaps.

    • Main Results:

    • Partial-thickness defects show encouraging results and early clinical translation.
    • Full-thickness, circumferential esophageal defects present significant challenges, including stenosis and leakage.
    • Regeneration of muscular and neuromuscular structures in full-thickness defects is incomplete.

    Conclusions:

    • Esophageal tissue engineering is a promising strategy, but challenges remain for full-thickness defect reconstruction.
    • Further preclinical and translational research is essential for developing standardized circumferential esophageal replacement.
    • Transparent reporting of experimental outcomes is crucial for clinical translation.