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High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
Published on: May 5, 2014
Targeting TLR2 agonists as immunomodulators with broad antiviral activity
Nongthombam Boby1, Bapi Pahar2
1Department of Developmental Biology and Genetics, Indian Institute of Science, Bengaluru, Karnataka 560012, India.
Abstract:
Toll-like receptor-2 (TLR2) serves as an innate immune sensor that recognizes specific viral proteins, thereby initiating signaling pathways that can either enhance antiviral host defenses or induce pathological inflammatory responses. In this forum, we discuss the role of TLR2 and its agonists in enhancing antiviral and vaccine-induced immune responses.
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