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Updated: Apr 4, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Catalytic Asymmetric Allylation of Cyclopropanols with Allyl Alcohols
Dan Jiang1,2, Hongbing Xiong1, Wenliang Zeng1
1Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Innovative Drug Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China.
Abstract:
Herein, we report an iridium-catalyzed direct asymmetric ring-opening allylation of cyclopropyl alcohols with free allyl alcohols. The catalytic system, consisting of [Ir(cod)Cl]2, Carreira phosphoramidite ligand, and Fe(ClO4)2·xH2O, enables efficient formation of β-allyl-substituted carbonyl compounds in good yields with excellent enantioselectivities (up to >99% ee). The method exhibits a broad substrate scope, tolerating diverse phenylvinylcarbinol derivatives and both aryl- and alkyl-substituted cyclopropanols.
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