From Biobank to "Bio-Think-Tank": Functional Evolution of UK Biobank in Public Health Policy Making

This study aims to explore the evolving role of the UK Biobank in public health policymaking, particularly its shift from a traditional biobank to a proactive "bio-think tank" and highlight the drivers and necessary elements of this evolution, with a focus on improving its functional impact on policymaking.

Searches were performed in PubMed, Scopus and Google Scholar databases (end of search: August 20, 2025). We followed guidelines for the PRISMA. We identified 683 potentially relevant titles in our search and selected 51 studies in our review, reflecting "bio-think-tank" issues between January 2004 and August 2025.

Using a functionalist framework, the study identifies key factors driving the UK Biobank's evolution: limited real-time decision support, rising stakeholder expectations, and the UK's desire to lead in biobank science. It defines the "bio-think tank" concept and contrasts it with traditional biobanks.

The UK Biobank's evolution should focus on improving data quality, public trust, accessibility for policymakers, and cross-sector collaboration to strengthen its role as a national research hub and global model for integrating biobank resources with health governance.