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Beyond Efficacy: 0.6% Selenium Disulfide Shampoo Matches 2% Ketoconazole for Seborrheic Dermatitis with Superior
Journal of Drugs in Dermatology : JDD
|April 3, 2026
Summary
A new micronized selenium disulfide (SeS2) shampoo matches ketoconazole shampoo
Area of Science:
- Dermatology
- Cosmetic Science
Background:
- Dandruff shampoos can cause hair dryness and manageability issues.
- This can affect patient adherence and treatment success.
Purpose of the Study:
- Compare the efficacy, tolerability, and cosmetic benefits of 0.6% micronized selenium disulfide shampoo (SeS2) against 2% ketoconazole shampoo.
- Evaluate shampoo performance in subjects with moderate to severe dandruff.
Main Methods:
- A 6-week, randomized, double-blind study.
- Involved 87 participants with moderate to severe dandruff.
- Compared 0.6% SeS2 shampoo to 2% ketoconazole shampoo.
Main Results:
- Both shampoos significantly reduced dandruff scales and seborrheic dermatitis symptoms (P<0.001).
- Pruritus severity scores improved similarly for both treatments.
- SeS2 shampoo offered superior cosmetic benefits, leaving hair softer and glossier (P<0.001).
Conclusions:
- 0.6% micronized SeS2 shampoo is as effective as 2% ketoconazole shampoo for scalp seborrheic dermatitis.
- SeS2 shampoo provides better cosmetic results across various hair types.
- This offers a more cosmetically pleasing option for dandruff treatment.
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