INDIVIDUAL ARTICLE: Real World Use of Topical Tranexamic Acid Serum in Patients With Hyperpigmentation

Hyperpigmentation and pigmentary alterations are common dermatologic concerns that remain difficult to treat. The modernized topical tranexamic acid serum (TNXA-SHOT) is a novel, patent-pending serum that contains 5% tranexamic acid, 1% amino acid, and 3% endophytol, which have been shown to mediate various biological pathways of the mechanism of action involved in the pigment production process. These three active ingredients aim to fight key hyperpigmentation triggers: inflammation, hormonal imbalance, and environmental pollution. The following real-world case series aims to demonstrate the use of TNXA-serum under real-world conditions in a split-face, integrated skincare regimen with a procedure. Eight expert dermatologists shared their experience pairing the new serum with pigment-targeting procedures (eg, non-ablative laser, microneedling, and salicylic acid peel) to improve patient pigmentary outcomes. The real-world cases demonstrate that application of TNXA-serum to the face after in-office procedures may accelerate improvement in dyspigmentation while offering added benefits of improved skin texture and radiance. These real-world cases serve as a valuable guide for patients and dermatologists to help form targeted, effective, and safe pigment-targeting integrated skincare plans.  .