Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

5.8K
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
5.8K
Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

2.7K
2.7K
Microtubules in Signaling01:22

Microtubules in Signaling

2.3K
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
2.3K
Classification of Epithelial Tissues: Simple Epithelium01:30

Classification of Epithelial Tissues: Simple Epithelium

16.5K
Simple epithelium consists of a single layer of cells that lines body cavities and blood vessels. The shape of the cells in the epithelium reflects the function of the tissue. Cells in simple squamous epithelium appear as thin scales with flat, elliptical nuclei that mirror the form of the cell.
Because of the thinness of the cells, simple squamous epithelium is present where the rapid passage of chemical compounds is observed. For example, the endothelium that lines the capillaries and vessels...
16.5K
Microtubules in Cell Motility01:24

Microtubules in Cell Motility

5.0K
Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
5.0K
Classification of Epithelial Tissues: Stratified Epithelium01:29

Classification of Epithelial Tissues: Stratified Epithelium

15.8K
Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
15.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-Assembled Hydrogels Developed from THPA-γ<sup>4</sup>-Phe-γ<sup>4</sup>-Phe-OH Loaded with Icariin Promote Chronic Diabetic Wound Healing in Mice.

ACS applied bio materials·2026
Same author

Methoxy flavonoids inhibits proliferation and induces apoptosis of A549 lung cancer cells.

Journal of complementary & integrative medicine·2026
Same author

Unveiling the anti-inflammatory wound healing potential of Ocimum canum extract and its phytochemicals via bioassay-guided isolation, fractionation, and computational studies.

Scientific reports·2025
Same author

Anti-Inflammatory Activity of Novel Dehydrozingerone-6 (DHZ-6) Through Modulation of iNOS, COX-2, and NF-κB/p65 in LPS-Stimulated Macrophages and In Vivo Acute Lung Injury Murine Model.

Journal of applied toxicology : JAT·2025
Same author

Novel Semisynthetic Derivative of Dehydrozingerone (DHZ-15) Modulates Lipopolysaccharide-Stimulated Macrophages by Targeting the NF-κB/p65 Pathway and In Vivo Evaluation in a Sepsis BALB/c Model.

Clinical and experimental pharmacology & physiology·2025
Same author

5-(3, 4-methylenedioxyphenyl)-4-ethyl-2E, 4E-pentadienoic acid piperidide as MdeA efflux pump inhibitor of Staphylococcus aureus.

Biochimie·2025
Same journal

Hidden Messages in Extracellular Vesicles: Cross-Kingdom RNA Communication in Plant and Microbe Interactions.

Annual review of cell and developmental biology·2026
Same journal

mRNA-Scaffolded Cytoplasmic Compartments.

Annual review of cell and developmental biology·2026
Same journal

Developmental Programming of Human Kidney Function.

Annual review of cell and developmental biology·2026
Same journal

The Translation of Genetic Information in Neurodevelopment.

Annual review of cell and developmental biology·2026
Same journal

The Origin and Early Evolution of Fungi: Challenges, Inferences, and Principles.

Annual review of cell and developmental biology·2026
Same journal

Interstitial Spaces: A Basolateral Source of Structure and Signals.

Annual review of cell and developmental biology·2026
See all related articles

Related Experiment Video

Updated: Apr 5, 2026

In vivo Evaluation of Mucociliary Clearance in Mice
06:35

In vivo Evaluation of Mucociliary Clearance in Mice

Published on: December 18, 2020

4.9K

Specification of Ciliated Cells.

Hao Lu1, Govind Yadav2, Sudipto Roy1,3

  • 11Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore;

Annual Review of Cell and Developmental Biology
|April 3, 2026
PubMed
Summary
This summary is machine-generated.

Cilia, crucial for early eukaryotes, evolved into distinct types in vertebrates: sensory primary cilia and motile cilia. Understanding ciliated cell specification offers insights into treating ciliopathies.

More Related Videos

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo
08:00

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo

Published on: July 13, 2015

12.8K
Ex vivo Method for High Resolution Imaging of Cilia Motility in Rodent Airway Epithelia
08:25

Ex vivo Method for High Resolution Imaging of Cilia Motility in Rodent Airway Epithelia

Published on: August 8, 2013

21.8K

Related Experiment Videos

Last Updated: Apr 5, 2026

In vivo Evaluation of Mucociliary Clearance in Mice
06:35

In vivo Evaluation of Mucociliary Clearance in Mice

Published on: December 18, 2020

4.9K
Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo
08:00

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo

Published on: July 13, 2015

12.8K
Ex vivo Method for High Resolution Imaging of Cilia Motility in Rodent Airway Epithelia
08:25

Ex vivo Method for High Resolution Imaging of Cilia Motility in Rodent Airway Epithelia

Published on: August 8, 2013

21.8K

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Evolutionary Biology

Background:

  • The last common eukaryotic ancestor likely possessed cilia for locomotion and sensation.
  • Metazoans, especially vertebrates, exhibit a specialization of cilia into immotile primary cilia (sensory/signaling) and motile cilia (fluid flow/locomotion).

Purpose of the Study:

  • To review mechanisms regulating ciliated cell specification.
  • To focus on ciliogenic transcriptional networks and inductive signals.
  • To discuss human disorders linked to ciliated cell misspecification and potential therapeutic strategies for ciliopathies.

Main Methods:

  • Literature review of ciliated cell specification.
  • Analysis of transcriptional networks and inductive signaling pathways.
  • Highlighting human genetic disorders and ciliopathies.

Main Results:

  • Ciliated cell specification involves complex transcriptional networks and inductive signals.
  • Distinct cell lineages utilize specific pathways for ciliated cell development.
  • Cilia dysfunction leads to various human diseases, termed ciliopathies.

Conclusions:

  • Understanding ciliated cell specification is key to comprehending vertebrate evolution and function.
  • Dysregulation of these pathways underlies significant human health issues.
  • Targeting ciliated cell specification mechanisms may offer therapeutic avenues for ciliopathies.