Multifunctional nanozyme systems for combating bacterial infections in wound treatment

Bacterial penetration of the wound surface results in acute and chronic infections and in delayed wound healing. Patients' quality of life declines, and healthcare systems throughout the world are under increased stress. Novel artificial enzymes called nanozymes are capable of controlling the wound microenvironment and effectively mimicking the activity of natural enzymes. They have the advantages of being very steady and affordable. They speed up the healing of infected wounds, restore blood vessels, and reduce oxidative stress and blood glucose levels. Nanozyme-based therapy is a potentially successful wound-treatment strategy when combined with other components. This article reviews important data on the development of chronic wounds and on the potential of nanozyme technology for their treatment. It provides new insights into the rapidly growing field and will help researchers to choose nanozyme design strategies depending on the desired therapeutic outcome in wound healing. Finally, it examines methods for enhancing the current nanozyme-based treatment techniques and provides an overview of the most recent developments in nanozyme-based wound therapy.