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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Measuring Local Anaphylaxis in Mice
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Anaphylaxis Epidemiology and Risk Factors.

Neil R Patel1, Julie Wang1

  • 1Division of Pediatric Allergy & Immunology, Kravis Children's Hospital, Elliot and Roslyn Jaffe Food Allergy Institute, New York, NY, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1198, New York, NY 10029, USA.

Immunology and Allergy Clinics of North America
|April 3, 2026
PubMed
Summary
This summary is machine-generated.

Anaphylaxis, a severe allergic reaction, is increasing globally due to various factors. Understanding its changing patterns helps identify high-risk individuals for better treatment strategies.

Keywords:
AnaphylaxisEpidemiologyRisk factor

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Area of Science:

  • Allergy and Immunology
  • Epidemiology
  • Public Health

Background:

  • Anaphylaxis is a critical, life-threatening allergic reaction impacting all age groups.
  • Global prevalence of anaphylaxis is rising, influenced by diagnostic improvements, new treatments, and environmental shifts.
  • Epidemiological patterns of anaphylaxis vary significantly based on the specific trigger.

Purpose of the Study:

  • To analyze the current epidemiology of anaphylaxis.
  • To identify factors contributing to the increasing prevalence of anaphylaxis.
  • To highlight risk factors associated with severe or fatal anaphylaxis.

Main Methods:

  • Review of global research and epidemiological data on anaphylaxis.
  • Analysis of contributing factors to prevalence changes.
  • Identification and categorization of risk factors for severe anaphylaxis.

Main Results:

  • Anaphylaxis prevalence is increasing worldwide, driven by improved diagnostics, therapies, climate change, and guideline updates.
  • Older age, lung disease, cardiovascular conditions, and certain medications (beta-blockers, ACE inhibitors) are linked to severe anaphylaxis.
  • Risk factors and prevalence differ based on the anaphylactic trigger.

Conclusions:

  • Understanding anaphylaxis epidemiology is crucial for public health strategies.
  • Identifying high-risk populations can guide preventative measures and therapeutic interventions.
  • Further research into anaphylaxis triggers and risk stratification is warranted.