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Updated: Apr 5, 2026

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
Published on: June 5, 2020
First Report of Human Hepatitis B Virus (HBV) in Wild Neotropical Primates
Jean P Boubli1, Hani Rocha El Bizri2, Luan F Botelho-Souza3
1School of Science, Engineering and the Environment, University of Salford, Salford, Greater Manchester, UK. j.p.boubli@salford.ac.uk.
Abstract:
Globalization and environmental change are reshaping infectious disease dynamics, including reverse zoonotic transmission from humans to wildlife. We assessed hepatitis B virus (HBV) infection in wild New World primates from two Brazilian Amazon regions: an anthropogenically impacted area in southwestern Amazonia (Rondonia and Mato Grosso states) and a remote, minimally impacted area along the upper Japurá River (Amazonas state). Blood or liver samples from 88 primates representing 28 species were examined for HBV. HBV was detected in 17 of 49 primates (34.7%) from disturbed areas but in none of the 39 primates from the remote site. Human population density significantly predicted infection, and viral genotypes matched locally circulating human HBV strains, supporting human-to-primate spillover driven by deforestation and encroachment.
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