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Updated: Apr 5, 2026

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes
Published on: January 12, 2024
Antibacterial PROTACs: the road ahead for next-generation antibiotics?
Andrea Milelli1, Simone Raimondi2, Somayeh Asgharpour3
1Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Rimini, Italy.
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The discovery of antibiotics revolutionized modern medicine, enabling the treatment of once-deadly bacterial infections. However, the rise of antibiotic-resistant bacteria has severely limited their effectiveness, making antimicrobial resistance (AMR) a major global health challenge. Developing new antibiotics with novel mechanisms of action is notably difficult. A promising approach is targeted protein degradation (TPD), a technology that has transformed drug discovery and shown success in cancer, neurodegenerative diseases, and immunology. In this review, we explore the potential of TPD to create next-generation antibacterials, its advantages over conventional antibiotics, and current research on prokaryotic protein degradation systems and BacPROTAC molecules.
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