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Updated: Apr 5, 2026

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Self-Immolative Gels: Programmable Degradation Using Self-Immolative Linkers and Polymers.

Chuanfeng Li¹, Elizabeth R Gillies^1,2

¹Department of Chemistry, The University of Western Ontario, London, Ontario, Canada.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|April 4, 2026

Summary

This summary is machine-generated.

Self-immolative linkers (SILs) and polymers (SIPs) enable controlled gel property changes. This chemistry is harnessed for advanced applications in responsive materials and drug delivery systems.

Keywords:

degradable drug delivery gels hydrogels polymers self‐immolative

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Area of Science:

Materials Science
Polymer Chemistry
Supramolecular Chemistry

Background:

Gels possess diverse structures and properties, enabling applications in pollution control and regenerative medicine.
Stimulus-triggered gel property modulation is key for functions like sensing and drug release.
Self-immolative linkers (SILs) and polymers (SIPs) utilize reaction cascades for amplified responses to stimuli.

Purpose of the Study:

To introduce the fundamental chemistry of SILs and SIPs.
To present the incorporation of SILs and SIPs into gel systems.
To discuss the potential applications of these responsive gel systems.

Main Methods:

Review of SIL and SIP chemistry fundamentals.
Discussion of SIL incorporation via cargo modification and cross-linking.
Analysis of SIP organogel and hydrogel formation strategies.

Main Results:

SILs and SIPs can be integrated into gels for controlled property modulation.
Strategies for creating SIP-based organogels and hydrogels are presented.
The chemistry enables tunable responses for specific applications.

Conclusions:

SIL and SIP chemistry offers a powerful platform for designing advanced functional gels.
Further research can expand the applications of these responsive materials.
The field holds significant promise for future innovations in materials science.