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Incidence and Risks of Chronic Rhinosinusitis in Head and Neck Cancer: A Meta-Analysis
John Dewey1, Heli Majeethia2, Kushal Modi3
1Department of Otolaryngology-Head and Neck Surgery, West Virginia University, Morgantown, West Virginia, USA.
The Laryngoscope
|April 4, 2026
Summary
Chronic rhinosinusitis (CRS) affects 37% of head and neck cancer (HNC) patients. Nasopharyngeal cancer, radiation, and chemotherapy significantly increase CRS risk.
Area of Science:
- Otolaryngology
- Oncology
- Epidemiology
Background:
- Chronic rhinosinusitis (CRS) is a known complication in head and neck cancer (HNC) patients.
- Understanding the incidence and risk factors for CRS in this population is crucial for patient management.
Purpose of the Study:
- To systematically review and identify the incidence and risk factors associated with CRS in adult patients diagnosed with HNC.
Main Methods:
- A systematic literature search was conducted across PubMed, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials.
- Seventeen studies involving 3685 patients were included, adhering to PRISMA guidelines.
- Data on CRS diagnosis, incidence, and associated risk factors were extracted and analyzed.
Main Results:
- The overall pooled incidence of CRS in HNC patients was 0.37, with significant heterogeneity in diagnostic methods.
- Incidence was higher in nasopharyngeal cancer (NPC) patients (0.45) compared to other HNC types (0.18).
- Radiation therapy (log OR=1.46), concurrent chemotherapy, and advanced disease stage were identified as significant risk factors for CRS.
Conclusions:
- The study confirms that NPC, radiation therapy, advanced disease stage, and concurrent chemotherapy are significant risk factors for developing CRS in HNC patients.
- Healthcare providers should maintain a high index of suspicion for CRS in HNC patients undergoing these treatments.
- Further research may be needed to standardize CRS diagnosis in this patient cohort.
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