Related Experiment Video

Updated: Apr 6, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

14.4K

Unveiling the epigenetic landscape: transforming renal cell carcinoma treatment

Fengyu Zhang1,2, Haifeng Ni3, Yumeng Lin4

  • 1TCM Prevention and Treatment of Metabolic and Chronic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Clinical Epigenetics
|April 4, 2026
PubMed

Insights

Epigenetic mechanisms, including DNA, histone, and RNA modifications, significantly impact renal cell carcinoma (RCC) development and drug resistance. Understanding these epigenetic factors offers promising avenues for novel RCC therapies.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Renal cell carcinoma (RCC) presents global health challenges due to its complex development and resistance to treatments.
  • Understanding RCC pathogenesis is crucial, given its atypical presentation and susceptibility to drug resistance.

Purpose of the Study:

  • To review recent literature on epigenetic regulation in RCC.
  • To summarize the properties and functions of epigenetic mechanisms in RCC.
  • To highlight the clinical applications of epigenetic regulation in RCC.

Main Methods:

  • Comprehensive literature review of recent publications.
  • Analysis of epigenetic mechanisms including DNA, histone, and noncoding RNA modifications.
  • Focus on the role of epigenetics in RCC progression and treatment resistance.

Main Results:

  • Epigenetic modifications are key regulators in the development and progression of RCC.
  • Specific epigenetic alterations influence RCC's atypical presentation and drug resistance.
  • Epigenetic mechanisms present significant potential for clinical applications in RCC management.

Conclusions:

  • Epigenetic regulation plays a critical role in renal cell carcinoma.
  • Targeting epigenetic mechanisms offers a promising strategy for novel RCC therapies.
  • Further research into epigenetic modifications could lead to improved clinical outcomes for RCC patients.
Keywords:
DNA methylationHistone modificationsNcRNAsRNA modificationsRenal cell carcinoma

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