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Nonstandard Donors With Acceptable Risk for Infectious Disease in Kidney And Kidney-Pancreas Transplants: A Promising
Alma Iafisco1, Marta Di Giovanni1, Roberto Colonnelli1
1UOC Nefrologia Dialisi e trapianto di Rene, P.O.I.T., Azienda Ospedaliera San Camillo Forlanini, Roma, Italy.
Transplantation Proceedings
|April 5, 2026
Summary
Kidney transplant organ shortage is a growing concern. This study shows that using carefully selected nonstandard donors with acceptable risks can lead to successful transplants with outcomes comparable to standard donors, improving patient survival and quality of life.
Area of Science:
- Nephrology
- Transplantation Immunology
- Public Health
Background:
- Increasing demand for kidney transplants strains organ availability.
- Nonstandard donors, previously excluded, are now considered.
- Transplants from nonstandard donors show improved outcomes over dialysis.
Purpose of the Study:
- Investigate outcomes of kidney transplants from nonstandard donors with acceptable risks.
- Focus on donors with increased infectious risk.
- Evaluate infectious disease transmission, post-transplant mortality, and graft function.
Main Methods:
- Retrospective analysis of 51 kidney transplants (including 2 kidney-pancreas).
- Donors classified as nonstandard with acceptable risk profiles.
- Evaluation of infectious disease transmission, infection-related mortality, and graft function at 44 weeks.
- Comparison with a control group of standard donor recipients.
Main Results:
- Strict precautions minimized donor-derived infections and infection-related mortality.
- Renal function at 44 weeks post-transplant was comparable to standard donor recipients.
- No significant increase in infectious complications observed.
Conclusions:
- Cautious use of acceptable risk donor organs is a viable strategy for organ shortage.
- This approach ensures acceptable post-transplant outcomes and patient safety.
- Nonstandard donors can effectively improve kidney transplant rates and patient well-being.
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