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Updated: Apr 7, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Optimization of novel quinazolinone derivatives as CRBN E3 ligase modulators for enhanced degradative activity and

Peng Chen1, Hongkang Peng1, Chen Liu2

  • 1School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China; NHC Key Laboratory of Birth Defect Research and Prevention & MOE Key Lab of Rare Pediatric, Disease, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.

Bioorganic Chemistry
|April 5, 2026
PubMed

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