Tailoring triazine-based covalent organic framework with hydroxyl sites for effective extraction and sensitive...

Phenolic endocrine disrupting compounds (PEDCs) are associated with significant health hazards, necessitating the development of highly sensitive analytical detection methodologies‌. This study reported a novel covalent organic framework (DT-COF) by strategically incorporating hydroxyl-rich building blocks into π-conjugated architectures. DT-COF demonstrated enhanced adsorption effect for PEDCs through the multiple hydrogen bond binding and multiple π-π interaction sites. By using DT-COF as a solid phase extraction adsorbent and integrating it with high performance liquid chromatography tandem the mass spectrometry, a robust analytical platform was provided to determine the trace PEDCs in green tea beverages, bottled water, and milk. Under optimized conditions, the method exhibited excellent analytical performance, including a low detection limit (0.018-0.219 ng mL^-1), good recovery rates (86.3-109%), and outstanding reproducibility (RSDs ≤6.6%). This study achieves dual objectives: enabling sensitive detection of PEDCs contaminants while pioneering functional COF material development.