Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.9K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.9K
Cancer Therapies02:49

Cancer Therapies

10.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.6K
Cancer Therapies02:49

Cancer Therapies

3.0K
3.0K
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

1.5K
1.5K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.3K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.3K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.4K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Astrocytes in neuroinflammation and brain cancer.

Molecular biomedicine·2026
Same author

Reprogramming neural-tumor crosstalk: emerging therapeutic dimensions and targeting strategies.

Military Medical Research·2025
Same author

TRAILblazing Astrocytes: Glioblastoma's Covert Immunosuppressive Agents.

Neuroscience bulletin·2025
Same author

Liver cirrhosis: molecular mechanisms and therapeutic interventions.

MedComm·2024
Same author

Maize lipid droplet-associated protein 2 is recruited by a virus to enhance viral multiplication and infection through regulating cellular fatty acid metabolism.

The Plant journal : for cell and molecular biology·2024
Same author

2,2',4,4'-Tetrabromodiphenyl ether exposure disrupts blood-testis barrier integrity through CMA-mediated ferroptosis.

The Science of the total environment·2024

Related Experiment Video

Updated: Apr 7, 2026

Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy
11:24

Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy

Published on: October 18, 2011

15.3K

Cancer Neuroscience: Innovative Conception and Emerging Strategy of Therapy.

Ting Wang1,2, Zikai Dong1,2, Yongfei Wang1,2

  • 1The First Clinical Medical College of Lanzhou University Lanzhou China.

Medcomm
|April 6, 2026
PubMed
Summary

Cancer neuroscience explores how the nervous system impacts cancer. This review expands understanding of nerve-tumor interactions, including new pathways and the gut-brain-immune axis, for novel cancer therapies.

Keywords:
brain–bodycomorbiditydrug repurposingneuro‐microbic‐oncologyperineural invasiontumor microenvironment

More Related Videos

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
10:10

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Published on: October 18, 2011

13.2K
Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model
09:57

Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model

Published on: June 4, 2017

12.9K

Related Experiment Videos

Last Updated: Apr 7, 2026

Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy
11:24

Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy

Published on: October 18, 2011

15.3K
Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
10:10

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Published on: October 18, 2011

13.2K
Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model
09:57

Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model

Published on: June 4, 2017

12.9K

Area of Science:

  • Neuroscience
  • Oncology
  • Immunology

Background:

  • Cancer neuroscience reveals the nervous system's active role in tumor development.
  • Bidirectional neuron-cancer cell interactions influence tumorigenesis, metastasis, and therapy response.

Purpose of the Study:

  • Synthesize current understanding of nerve-tumor interactions.
  • Propose an expanded classification scheme for these interactions.
  • Integrate neurobiology, oncology, and immunology for novel therapeutic strategies.

Main Methods:

  • Literature review synthesizing current research.
  • Proposal of an expanded classification scheme for nerve-tumor interactions.
  • Discussion of mechanisms including electrochemical signaling, paracrine communication, and neuroimmune modulation.

Main Results:

  • Identified perineural invasion as a unique metastatic pathway.
  • Incorporated neuro-microbic-oncology and the gut-brain-immune axis.
  • Highlighted contributions to cancer-associated comorbidities like pain and cachexia.

Conclusions:

  • Nerve-tumor interactions are crucial in cancer progression and comorbidities.
  • Emerging neurotherapeutic strategies offer potential for improved outcomes.
  • An integrated framework informs the development of nerve-targeted cancer therapies.