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Multiple Vertebral Fractures After One Dose of Denosumab
Jaime Leigh Ryan1, Leslie S Eldeiry1,2
1Department of Endocrinology, Atrius Health, Boston, Massachusetts.
A single dose of denosumab can cause severe rebound vertebral fractures after discontinuation. This case highlights the need for careful follow-up planning for all patients on denosumab therapy, regardless of dose or duration.
Area of Science:
- Endocrinology
- Nephrology
- Orthopedics
Background:
- Denosumab is a bone resorption inhibitor used for osteoporosis and hypercalcemia.
- Discontinuation of denosumab is associated with a rebound phenomenon, increasing fracture risk.
- The rebound effect after a single denosumab dose has not been previously reported.
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