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Related Concept Videos

Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

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The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
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Gastritis-I: Introduction and Types01:27

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Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Gastrointestinal Involvement in Adult IgA Vasculitis: A Comprehensive Review.

Supritha Chintamaneni1, Praveen Wickremasinghe2, Batool Mubashar3

  • 1Internal Medicine, HCA Houston Healthcare Kingwood, Houston, USA.

Cureus
|April 6, 2026
PubMed
Summary

Immunoglobulin A vasculitis (IgAV) in adults, especially with gastrointestinal (GI) involvement, requires early recognition. This review synthesizes literature on adult IgAV, covering its mechanisms, diagnosis, and management for better outcomes.

Keywords:
corticosteroid and immunosuppressive treatmentgastrointestinal involvementiga vasculitis (igav)immune complex depositionprognostic biomarkers

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Area of Science:

  • Rheumatology
  • Gastroenterology
  • Immunology

Background:

  • Immunoglobulin A vasculitis (IgAV), previously Henoch-Schönlein purpura (HSP), is a small-vessel vasculitis characterized by IgA immune complex deposition.
  • While more common in children, IgAV is more severe and less understood in adults, particularly concerning gastrointestinal (GI) tract involvement.

Purpose of the Study:

  • To synthesize current literature on adult IgAV with GI involvement.
  • To provide a comprehensive overview of epidemiology, immune mechanisms, genetics, diagnosis, treatment, and prognosis.

Main Methods:

  • Literature synthesis of current research on adult IgAV and GI involvement.
  • Review of epidemiological data, pathomechanisms, diagnostic tools, and therapeutic strategies.

Main Results:

  • Adult GI IgAV affects 37-65% of cases, presenting with diverse GI symptoms and potential severe complications like perforation.
  • Diagnosis involves laboratory markers (CRP, NLR, D-dimer) and imaging (CT, endoscopy).
  • Corticosteroids are primary treatment; immunosuppressants and surgery are reserved for severe or refractory cases.

Conclusions:

  • Adult GI IgAV necessitates a multidisciplinary approach for effective management.
  • Prognostic factors include age, renal involvement, and genetic markers.
  • Further research into biomarkers and novel therapies is crucial for improving patient outcomes.