Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic value of subretinal hyperreflective material as an imaging biomarker in the treatment of neovascular age-related macular degeneration: A systematic review.

Survey of ophthalmology·2026
Same author

Comparative Outcomes of Immediate Versus Delayed Sequential Bilateral Cataract Surgery: A Narrative Review.

Cureus·2026
Same author

Corneal Endothelium Cell Loss After Ahmed and Baerveldt Glaucoma Drainage Device Implantation: A Systematic Review and Meta-analysis.

Journal of glaucoma·2026
Same author

Visual Performance Comparison Between Enhanced Monofocal and Extended Depth of Focus Intraocular Lenses: A Systematic Review and Meta-Analysis.

Cureus·2026
Same author

Prophylactic Laser and Cryotherapy in the Fellow Eye of Patients With Giant Retinal Tears: A Systematic Review and Meta-Analysis.

Cureus·2025
Same author

Use of Povidone-Iodine Solution for Intraoperative Antisepsis: A Systematic Review.

Cureus·2025

Related Experiment Video

Updated: Apr 7, 2026

Transcanalicular Diode Laser-assisted Dacryocystorhinostomy for the Treatment of Primary Acquired Nasolacrimal Duct Obstruction
07:30

Transcanalicular Diode Laser-assisted Dacryocystorhinostomy for the Treatment of Primary Acquired Nasolacrimal Duct Obstruction

Published on: October 13, 2017

11.8K

Tranexamic Acid in Dacryocystorhinostomy: A Systematic Review.

Angeliki Kollatou1, Konstantina N Sorkou2,1, Argyrios Tzamalis3,1

  • 1Ocular Surgery, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, GRC.

Cureus
|April 6, 2026
PubMed
Summary

Tranexamic acid (TXA) may reduce bleeding and surgical time in dacryocystorhinostomy (DCR). However, evidence is limited by small studies and subjective measures, necessitating further research for definitive conclusions.

Keywords:
antifibrinolyticsdacryocystorhinostomyhemostasisintraoperative bleedingnasolacrimal duct obstructionsurgical field claritytranexamic acid

More Related Videos

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
06:19

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

Published on: May 31, 2024

1.9K
A Standardized Surgical Technique for Tessier Medial Transnasal Canthopexy
06:08

A Standardized Surgical Technique for Tessier Medial Transnasal Canthopexy

Published on: January 23, 2026

301

Related Experiment Videos

Last Updated: Apr 7, 2026

Transcanalicular Diode Laser-assisted Dacryocystorhinostomy for the Treatment of Primary Acquired Nasolacrimal Duct Obstruction
07:30

Transcanalicular Diode Laser-assisted Dacryocystorhinostomy for the Treatment of Primary Acquired Nasolacrimal Duct Obstruction

Published on: October 13, 2017

11.8K
Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
06:19

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

Published on: May 31, 2024

1.9K
A Standardized Surgical Technique for Tessier Medial Transnasal Canthopexy
06:08

A Standardized Surgical Technique for Tessier Medial Transnasal Canthopexy

Published on: January 23, 2026

301

Area of Science:

  • Ophthalmology
  • Surgical Innovation
  • Pharmacology

Background:

  • Dacryocystorhinostomy (DCR) for nasolacrimal duct obstruction (NLDO) often faces challenges with intraoperative bleeding, impacting surgical efficiency.
  • Tranexamic acid (TXA), an antifibrinolytic agent, is explored for its potential to mitigate bleeding in various surgical settings.

Purpose of the Study:

  • To systematically review randomized controlled trials (RCTs) evaluating the efficacy of tranexamic acid (TXA) in dacryocystorhinostomy (DCR).
  • To assess TXA's impact on intraoperative bleeding, surgical duration, and surgical field clarity during DCR procedures.

Main Methods:

  • A systematic review adhering to PRISMA guidelines.
  • Searched PubMed/MEDLINE, Cochrane, and Google Scholar databases up to March 30, 2025.
  • Included four RCTs with 286 patients comparing TXA (intravenous or topical) with placebo or alternative agents.

Main Results:

  • Two studies showed significant reductions in intraoperative hemorrhage and surgical duration with TXA (IV and topical).
  • One study found no significant difference in outcomes; another indicated superior efficacy of hydralazine and remifentanil over TXA.
  • Improvements in surgical field clarity and surgeon satisfaction were noted but not statistically significant.

Conclusions:

  • Tranexamic acid (TXA) shows potential for reducing intraoperative bleeding and surgical time in DCR via both intravenous and topical routes.
  • Current evidence is limited by small sample sizes, variable outcome measures, and subjective assessments.
  • Further high-quality research is needed to confirm efficacy and determine optimal dosing regimens for TXA in DCR.