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Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

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Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
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Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

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Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
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Hand hygiene01:23

Hand hygiene

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Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
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Standard Precaution01:26

Standard Precaution

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Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
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Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

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Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
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Related Experiment Video

Updated: Apr 7, 2026

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection
05:32

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection

Published on: September 21, 2015

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Antibiotic Prophylaxis in Dermatologic Surgery: Advisory Statement 2025 (APDSAS 2025).

Elliott Campbell1, Abinash Virk2, Sarah Lessard3

  • 1Dermatology Associates of Northern Kentucky, Florence, Kentucky.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|April 6, 2026
PubMed
Summary
This summary is machine-generated.

Updated guidelines for antibiotic prophylaxis in dermatologic surgery recommend use for high-risk patients and infected sites. New recommendations address antibiotic selection for penicillin-allergic patients and intraincisional clindamycin.

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Last Updated: Apr 7, 2026

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection
05:32

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection

Published on: September 21, 2015

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Area of Science:

  • Dermatologic Surgery
  • Infectious Disease Prevention
  • Evidence-Based Medicine

Background:

  • Evolving guidelines and evidence necessitate an update to antibiotic prophylaxis recommendations in dermatologic surgery.
  • Previous advisory statements require revision based on new data.

Purpose of the Study:

  • To issue an updated advisory statement on antibiotic prophylaxis in dermatologic surgery.
  • Incorporate updated guidelines from major medical associations.

Main Methods:

  • Conducted a structured literature review.
  • Convened a multidisciplinary team of specialists (dermatologic surgery, infectious diseases, pharmacy).
  • Developed evidence-based recommendations based on current data.

Main Results:

  • Prophylactic antibiotics remain recommended for high-risk cardiac/prosthetic joint conditions, infected surgical sites, or mucosal breaches.
  • Significant updates include antibiotic selection for penicillin-allergic patients.
  • New guidance on intraoperative intraincisional clindamycin in local anesthetic.

Conclusions:

  • Recommendations for antibiotic prophylaxis in dermatologic surgery are dynamic.
  • The 2025 advisory statement offers current, evidence-based guidance.
  • Acknowledged limitations due to predominantly retrospective data.