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Sulfur-centered non-covalent interactions: emerging themes and challenges from rotational spectroscopy
Jiaxin Tang1, Wen Wen1, Alberto Lesarri2
1School of Chemistry and Chemical Engineering, Chongqing University, Daxuecheng South Rd. 55, 401331 Chongqing, China. fengg@cqu.edu.cn.
Physical Chemistry Chemical Physics : PCCP
|April 7, 2026
Summary
Microwave spectroscopy precisely measures weak sulfur interactions, crucial for biochemistry and materials science. This technique offers detailed molecular insights, aiding computational model development and applications.
Area of Science:
- Chemistry
- Biochemistry
- Materials Science
Background:
- Non-covalent interactions involving sulfur are vital in chemistry and biology.
- Accurately characterizing these weak interactions is experimentally and theoretically challenging.
- Microwave spectroscopy offers high structural sensitivity for studying molecular clusters.
Purpose of the Study:
- To review advancements in studying sulfur-centered non-covalent interactions using rotational spectroscopy.
- To highlight microwave spectroscopy's utility in assessing weak interactions.
- To provide insights for computational modeling and applications.
Main Methods:
- Utilizing microwave (rotational) spectroscopy to study jet-cooled molecular clusters.
- Employing isotopic substitution to enhance structural analysis.
- Leveraging high-resolution spectral data for energetic and structural determination.
Main Results:
- Demonstrated the capability of microwave spectroscopy to precisely characterize sulfur-centered non-covalent interactions.
- Showcased isotopic-sensitive measurements for detailed structural and energetic assessments.
- Provided a testbed for validating computational models of weak interactions.
Conclusions:
- Microwave spectroscopy is a powerful tool for understanding sulfur-based non-covalent interactions.
- These findings advance the study of biochemistry, supramolecular chemistry, and crystal engineering.
- High-resolution rotational spectroscopy offers unique insights into weak molecular forces.
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