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Updated: May 6, 2026

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Predictive models for ICU patient readmission based on machine learning: A systematic review.

Zhixiang Zheng1, Wenjun Yan2, Kai Cao3

  • 1Infectious Diseases Department, The First Affiliated Hospital of Soochow University, Jiangsu, China.

Journal of the Intensive Care Society
|April 7, 2026
PubMed
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Artificial intelligence (AI) models show moderate-to-high predictive performance for critically ill patient readmissions. Despite high bias risk, AI models outperform traditional methods, aiding in better patient management and reduced readmissions.

Area of Science:

  • Medical Informatics
  • Clinical Prediction Models
  • Artificial Intelligence in Healthcare

Background:

  • Artificial intelligence (AI) prediction models integrate multi-dimensional clinical data to identify high-risk populations.
  • These models support individualized discharge planning and optimize follow-up interventions to reduce readmission risk.
  • The increasing number of AI models for critically ill patient readmissions necessitates a quality and applicability evaluation.

Purpose of the Study:

  • To systematically evaluate published studies on AI prediction models for critically ill patient readmissions.
  • To assess the quality, risk of bias, and applicability of these AI models in clinical practice.

Main Methods:

  • A comprehensive search of multiple databases (CNKI, PubMed, Web of Science, etc.) was conducted from 2020 to June 2025.
Keywords:
artificial intelligencecritically ill patientsmeta-analysisreadmissionsystematic review

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  • Data extraction included study design, data sources, predictors, model development, and performance metrics.
  • The Prediction Model Risk of Bias Assessment Tool (PROBAST) was used for bias and applicability assessment.
  • Main Results:

    • 31 studies with 31 AI prediction models for critically ill patient readmissions were included.
    • The pooled Area Under the Curve (AUC) for 24 validation models was 0.82 (95% CI: 0.77-0.87).
    • All included studies exhibited a high risk of bias, primarily due to reporting quality and applicability limitations.

    Conclusions:

    • AI prediction models demonstrate moderate-to-high predictive performance for critically ill patient readmissions.
    • AI models significantly outperform traditional prediction models in predictive accuracy.
    • Despite identified biases, AI models offer valuable decision support for clinical practice and future research.