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A Novel HLA-A Allele, HLA-A*24:672, Identified by Next Generation Sequencing
Bilkay Basturk1,2, Miray Kavuzlu1, Bircan Zengel1
1Tissue Typing and Transplantation Laboratory, Baskent University Adana Dr. Turgut Noyan Medical Center, Adana, Turkiye.
HLA
|April 7, 2026
Summary
The Human Leukocyte Antigen (HLA)-A*24:672 allele is distinguished from the HLA-A*24:424 allele by a single nucleotide substitution. This genetic variation occurs at codon 73 within exon 2.
Area of Science:
- Immunogenetics
- Molecular biology
Background:
- The Human Leukocyte Antigen (HLA) system plays a critical role in immune responses.
- Specific HLA alleles are associated with various immune-related conditions and drug hypersensitivities.
- Understanding variations within HLA alleles is crucial for personalized medicine.
Purpose of the Study:
- To characterize a novel HLA-A*24 allele, designated HLA-A*24:672.
- To identify the specific genetic differences between HLA-A*24:672 and a known related allele, HLA-A*24:424.
Main Methods:
- High-resolution HLA typing was performed.
- DNA sequencing was utilized to analyze the genetic makeup of the alleles.
- Comparative sequence analysis was conducted to pinpoint nucleotide differences.
Main Results:
- The HLA-A*24:672 allele was identified and sequenced.
- A single nucleotide substitution was detected in codon 73 of exon 2 when comparing HLA-A*24:672 to HLA-A*24:424.
- This substitution results in a distinct genetic profile for HLA-A*24:672.
Conclusions:
- HLA-A*24:672 represents a unique allele within the HLA-A*24 family.
- The identified nucleotide substitution is the sole distinguishing feature between HLA-A*24:672 and HLA-A*24:424.
- This finding contributes to the detailed cataloging of HLA polymorphism.
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