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TIM-3 in Cardiovascular Disease.

Laura I Yousif1, Aukje G Sijtema1, Margot J Chevalier1

  • 1Erasmus MC, Cardiovascular Institute, Thorax Center, Department of Cardiology, Rotterdam, The Netherlands.

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Summary
This summary is machine-generated.

T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) is an immune checkpoint influencing cardiovascular disease. Further research is needed to explore TIM-3 signaling for improving cardiovascular health.

Keywords:
Cardio-ImmunologyCardiovascular DiseaseHMGB1Immune CheckpointsMyocardial InfarctionTIM-3

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Area of Science:

  • Immunology
  • Cardiovascular Medicine

Background:

  • Immune checkpoints regulate immune responses in various diseases.
  • T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) is an immune checkpoint expressed on immune and non-immune cells.
  • TIM-3 has four known ligands, with binding that can be stimulatory or inhibitory.

Purpose of the Study:

  • To summarize current knowledge of TIM-3 in innate and adaptive immunity.
  • To compile emerging evidence of TIM-3's role in cardiovascular disease (CVD).

Main Methods:

  • Literature review of TIM-3's function in immune cells.
  • Compilation of studies investigating TIM-3 in cardiovascular conditions.

Main Results:

  • TIM-3 acts as a context-dependent modulator of immune reactions in atherosclerosis, myocardial infarction, and myocarditis.
  • TIM-3's ligands can be exposed upon cell damage or death.
  • TIM-3 may have functions within the cardiovascular system.

Conclusions:

  • TIM-3 is implicated in cardiovascular disease pathogenesis.
  • More mechanistic research is required to determine if TIM-3 signaling can be targeted to enhance cardiovascular health.