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Navigating medication adherence in chronic diseases.

Izabella Uchmanowicz^1,2, Maria Jędrzejczyk¹, Grzegorz K Jakubiak³

¹Department of Nursing, Faculty of Nursing and Midwifery, Wroclaw Medical University, Poland.

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University

|April 7, 2026

Summary

Medication adherence, crucial for chronic disease management, involves initiation, implementation, and discontinuation. Improving adherence requires comprehensive strategies addressing patient, therapy, and system factors for better health outcomes.

Keywords:

adherence chronic disease discontinuation implementation new technologies

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Area of Science:

Pharmacology
Health Services Research
Patient Adherence

Background:

Medication adherence is defined as taking medications as prescribed for therapeutic outcomes.
It encompasses initiation, implementation, and discontinuation phases.
Poor adherence in chronic diseases causes significant negative clinical, economic, and psychosocial consequences.

Purpose of the Study:

To review the literature on medication adherence.
To highlight the importance of adherence in clinical practice.
To present strategies for enhancing medication adherence in chronic disease management.

Main Methods:

Literature review of adherence assessment methods (direct and indirect).
Analysis of factors influencing adherence (patient-related, therapy-related, healthcare system-related).
Evaluation of strategies to improve adherence across all phases.

Main Results:

Non-adherence is a systemic healthcare challenge, not solely a patient issue.
Effective strategies must be comprehensive, addressing multiple barrier levels.
Successful interventions support initiation, improve implementation, and manage discontinuation.

Conclusions:

Improving medication adherence is vital for patient outcomes and quality of life.
Comprehensive, multi-level strategies are necessary for effective adherence improvement.
Addressing adherence barriers is key to mitigating the negative impacts of non-adherence.