The metabolism of arachidonic acid and diseases during pregnancy
Mengjiao Kuang1, Fei Fu2, Menghua Kuang3
1Department of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200123, China.
Abstract:
Arachidonic acid (AA) is an essential polyunsaturated fatty acid in humans and a key component of the phospholipid bilayer in cell membranes. Under various stimuli, AA is released from phospholipids; however, elevated levels of AA can act as inflammatory mediators, triggering inflammatory responses. During pregnancy, the placenta synthesizes large amounts of AA to play a critical role in fetal development, preparation for childbirth, and maternal-fetal adaptation. Here, we systematically review the biological mechanisms of AA during pregnancy and its potential involvement in related disorders. We aim to comprehensively elucidate the correlation between AA levels and both physiological and pathological changes during pregnancy. Our findings provide novel theoretical insights and potential therapeutic targets for the prevention and treatment of pregnancy-related complications. These research advances contribute to a deeper understanding of the pathogenesis of pregnancy-associated diseases and offer important scientific support for ensuring maternal and fetal health and safety.
More Related Videos
Related Concept Videos
Lipid-derived Compounds in the Human Body
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Overview of Fatty Acid Metabolism
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Cholesterol: Significance and Regulation
Considering cholesterol and...
Atherosclerosis III: Management
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion


