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Raman spectroscopy as a diagnostic tool for glioma: protocol for a systematic review

Corneliu Ovidiu Vrancianu1,2,3, Marian Necula1,4, Eduard Milea1

  • 1National Institute of Research and Development for Biological Sciences, 296 Splaiul Independentei, District 6, Bucharest, 060031, Romania.

Diagnostic and Prognostic Research
|April 8, 2026
PubMed
Summary

No abstract available in PubMed .

Keywords:
Brain neoplasmsGliomaHigh-grade gliomaMachine learningRaman spectroscopy

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Raman Spectroscopy: Overview01:20

Raman Spectroscopy: Overview

The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and the...
Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...

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