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Primary Cutaneous ALK-Negative Anaplastic Large Cell Lymphoma in a Filipino Male: Successful Treatment With
Krystel Angela A Olano1, Frances Beatrice L Alarilla1, Athena Laureen P Ballesteros2
1Research Institute for Tropical Medicine, Department of Dermatology, Alabang, Muntinlupa, Metro Manila, Philippines.
None:
Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a CD30-positive lymphoproliferative disorder typically presenting with localized nodules. We report a 65-year-old Filipino male with multiple lesions on the right lower leg and locoregional lymphadenopathy. Histopathology confirmed ALK-negative pcALCL. Due to comorbidities and limited access to standard therapies, the patient was treated with weekly gemcitabine and localized radiotherapy. Complete clinical response was achieved with no recurrence at 18 months follow-up. This case highlights combined gemcitabine and radiotherapy as an effective alternative in selected high-risk pcALCL patients, demonstrating durable disease control.
