Comparison of Intravenous and Nebulized Dexmedetomidine for Surgical Field Visualization in Functional Endoscopic...

Area of Science:

• Anesthesiology
• Otolaryngology
• Pharmacology

Background:

• Optimal surgical field visualization is crucial for functional endoscopic sinus surgery (FESS).
• Dexmedetomidine is evaluated for its efficacy in improving surgical conditions.
• Comparing intravenous (IV) and nebulized administration routes is key.

Purpose of the Study:

• To compare the efficacy of IV and nebulized dexmedetomidine for surgical field visualization in FESS.
• To assess hemodynamic responses, blood loss, and postoperative outcomes.
• To determine the optimal administration route for dexmedetomidine in FESS.

Main Methods:

• A randomized controlled trial involving 114 patients undergoing FESS.
• Patients were divided into three groups: nebulized dexmedetomidine, IV dexmedetomidine, and normal saline.
• Outcomes included surgical visualization, hemodynamic stability, blood loss, sedation, and postoperative complications.

Main Results:

• Both IV and nebulized dexmedetomidine provided optimal surgical field visualization.
• Nebulized dexmedetomidine maintained visualization longer (p < 0.05).
• IV dexmedetomidine showed a greater reduction in postoperative hemoglobin and hematocrit (p < 0.01).

Conclusions:

• Both IV and nebulized dexmedetomidine are effective for FESS, improving visualization and reducing complications.
• Nebulized dexmedetomidine offers extended surgical field visualization.
• IV dexmedetomidine is superior in maintaining postoperative hematological parameters.