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Author Spotlight: Advancing Mitochondrial Research - mtHyper7 Biosensor for Subcellular Analysis
Published on: June 2, 2023
A neutral BODIPY molecular rotor photosensitizer for mitochondrial targeting
Surendra Kumar1, Anjani Kumar1, Durgendra Yadav1
1Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, India. roopshikha.singh1@bhu.ac.in.
Abstract:
Herein, two novel neutral sulfone-BODIPY-based molecular rotors (SB1 and SB2) have been designed and synthesized, integrating viscosity-responsive turn-on fluorescence with ISC-driven ROS generation. The sulfone group acted as a strong electron acceptor to enhance ICT, while phenyl conjugation imparted fluorescence sensitivity through restricted rotation. These neutral sulfone-BODIPYs enable mitochondrial targeting and imaging and serve as potential photosensitizers for biomedical applications.
