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Resting-state brain connectivity following extra virgin olive oil intake in healthy adults: a randomised crossover
Rocío M Gutiérrez-Romero1,2, Carolina Donat-Vargas1,2,3,4, Emma Muñoz-Moreno5
1Polyphenol Research Group, Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, University of Barcelona (UB), 08028 Barcelona, Spain. rogutierrez@ub.edu.
Abstract:
This pilot randomised crossover neuroimaging substudy (n = 9) identified increased resting-state occipital functional connectivity following daily consumption of (poly)phenol-rich extra virgin olive oil compared with regular olive oil. Urinary hydroxytyrosol-glucuronide excretion increased significantly, and a significant interaction between intervention and metabolite levels was observed on occipital connectivity. These preliminary findings require replication in larger, adequately powered studies.
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