Related Experiment Video

Updated: Apr 9, 2026

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

17.8K

Modeling the Public Health Impact of Introducing 4CMenB Vaccination for Infants in the Brazilian National

Thatiana Pinto1, Zeki Kocaata2, Ana Medina3

  • 1GSK, Wavre, Belgium. thatiana.x.pinto@gsk.com.

Infectious Diseases and Therapy
|April 8, 2026
PubMed
Abstract

Insights

Introducing routine infant vaccination with the four-component meningococcal B vaccine (4CMenB) in Brazil could significantly reduce invasive meningococcal disease (IMD) cases and deaths across all age groups. This strategy is projected to avert over 63,000 IMD cases and 11,000 deaths.

Area of Science:

  • Public Health
  • Epidemiology
  • Vaccinology

Background:

  • Invasive meningococcal disease (IMD) caused by serogroup B (MenB) poses a significant threat, especially to infants in Brazil, where it is endemic.
  • The four-component MenB vaccine (4CMenB) offers potential cross-protection against other serogroups and is approved for individuals aged 2 months to 50 years.

Purpose of the Study:

  • To assess the public health impact of introducing routine infant vaccination with the 4CMenB vaccine in Brazil.
  • To model the reduction in IMD incidence, morbidity, and mortality across all age groups.

Main Methods:

  • A static, multigenerational, multicohort model using a discrete-time Markov approach over a 100-year horizon.
  • Incorporation of vaccine effectiveness, coverage, waning rates, and adjusted incidence data (2007-2023, excluding COVID-19).
  • Calculation of IMD-related deaths based on age-specific case fatality rates.

Main Results:

  • Infant 4CMenB vaccination is projected to avert 63,038 IMD cases (21% reduction) and 11,301 deaths (20% reduction) in all age groups, assuming 69% cross-protection against MenW.
  • A significant reduction of 21,408 MenB cases (43%) and 3335 deaths (43%) is predicted in infants (<1 year).

Conclusions:

  • Routine infant 4CMenB immunization in Brazil can substantially decrease IMD burden, improving long-term health outcomes.
  • This preventive measure reinforces the national immunization program's potential impact on reducing disease morbidity and mortality.
Keywords:
Neisseria meningitidisBrazilCross-protectionInvasive meningococcal diseasePublic health impact

More Related Videos

Mass Production of Genetically Modified Aedes aegypti for Field Releases in Brazil17:41

Mass Production of Genetically Modified Aedes aegypti for Field Releases in Brazil

Published on: January 4, 2014

25.8K
Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings04:16

Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings

Published on: February 7, 2025

1.0K

Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
54.1K
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.6K
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the...
51
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
4.9K
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
38
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
842