Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Methods of Documentation II: POMR01:26

Methods of Documentation II: POMR

1.6K
The Problem-Oriented Medical Record (POMR) revolutionized medical record-keeping by introducing a systematic approach focusing on the patient's problems rather than merely listing symptoms. Dr. Lawrence Weed's introduction of this method in the 1960s marked a significant advancement in medical documentation. The POMR framework consists of four key components: the database, problem list, plan of care, and progress notes.
1.6K
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

359
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
359
Group Therapy01:26

Group Therapy

708
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
708
Peptic Ulcer Disease V: Surgical Management and Nursing Care01:25

Peptic Ulcer Disease V: Surgical Management and Nursing Care

1.2K
Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease
1.2K
Interpersonal Psychotherapy01:25

Interpersonal Psychotherapy

601
Interpersonal psychotherapy (IPT) is a structured, time-limited therapeutic approach initially developed to treat depression. It integrates key concepts from psychodynamic, humanistic, and cognitive-behavioral therapies, making it a uniquely eclectic framework. The therapy is rooted in the interpersonal theories of Adolph Meyer and Harry Stack Sullivan, as well as John Bowlby's attachment theory, and focuses on the interplay between interpersonal relationships and emotional well-being.
601
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

615
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
615

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Concordance between genome-wide cfDNA screening and diagnostic test results for large copy-number variants: a multi-site study from the Global Expanded NIPT Consortium.

Frontiers in genetics·2026
Same author

Preimplantation genetic testing for meiotic aneuploidy in trophectoderm biopsies - is it time to change our approach?

Reproductive biomedicine online·2026
Same author

Gender Trends in Professional Advancement Among Academic Pediatric Neurologists.

JAMA network open·2025
Same author

<i>WUSCHEL-D1</i> upregulation enhances grain number by inducing formation of multiovary-producing florets in wheat.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Repeat cell-free DNA screening after initial false-positive results and term placental analysis for confined mosaicism: a prospective cohort study.

Archives of gynecology and obstetrics·2025
Same author

Presence of Micro- and Nanoplastics Affects Degradation of Chlorinated Solvents.

Toxics·2025
Same journal

Genetics in Reproduction.

Seminars in reproductive medicine·2026
Same journal

Genetics in Reproduction.

Seminars in reproductive medicine·2026
Same journal

Clinical Genetics in Reproductive Medicine: Variant Classification, Medically Actionable Genes, and Carrier Screening.

Seminars in reproductive medicine·2026
Same journal

Clinical Testing for Genetic Conditions.

Seminars in reproductive medicine·2026
Same journal

Genetics of Primary Ovarian Insufficiency.

Seminars in reproductive medicine·2026
Same journal

Genetic Basis and Heterogeneity of Congenital Hypogonadotropic Hypogonadism.

Seminars in reproductive medicine·2026
See all related articles

Related Experiment Video

Updated: Apr 10, 2026

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
09:30

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

3.7K

Understanding PGT-M: A Guide for Clinicians.

Amy Hill1,2, Alice Poulton3,4,5, Tristan Hardy1,2

  • 1Monash IVF Group Genetics, Repromed, Dulwich, Australia.

Seminars in Reproductive Medicine
|April 8, 2026
PubMed
Summary
This summary is machine-generated.

Preimplantation genetic testing for monogenic conditions (PGT-M) helps select unaffected embryos, reducing the chance of passing on genetic disorders. This reproductive option allows for biologically related children while minimizing pregnancy termination.

More Related Videos

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
08:20

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

14.8K
Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

1.3K

Related Experiment Videos

Last Updated: Apr 10, 2026

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
09:30

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

3.7K
MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
08:20

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

14.8K
Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

1.3K

Area of Science:

  • Reproductive Medicine
  • Medical Genetics
  • Embryology

Background:

  • Preimplantation genetic testing for monogenic conditions (PGT-M) screens in vitro embryos for specific inherited disorders.
  • It offers a reproductive choice for individuals at increased risk of having a child with a monogenic condition.
  • PGT-M enables the selection of unaffected embryos, reducing transmission risk and the need for pregnancy termination.

Purpose of the Study:

  • To provide a practical overview of PGT-M for clinicians.
  • To cover PGT-M's definition, regulations, technical aspects, and clinical application.
  • To explore PGT-M's limitations, ethical challenges, and user experiences.

Main Methods:

  • Review of existing literature and clinical guidelines on PGT-M.
  • Analysis of technical, clinical, practical, and ethical considerations in PGT-M provision.
  • Exploration of user experiences and challenges associated with PGT-M.

Main Results:

  • PGT-M is a preferred reproductive option for many individuals at risk of monogenic conditions.
  • Growing uptake necessitates clinician navigation of complex PGT-M considerations.
  • The review synthesizes information on PGT-M's scope, from lab work-up to clinical integration.

Conclusions:

  • PGT-M is a valuable tool for preventing the transmission of monogenic conditions.
  • Clinicians require comprehensive knowledge to effectively deliver PGT-M care.
  • Addressing limitations and ethical aspects is crucial for optimizing PGT-M services.