Metal-organic frameworks as versatile geobacter platforms for microbial protection and functionalization.

Area of Science:

• Biotechnology
• Materials Science
• Chemical Engineering

Background:

• Microorganisms are vital biocatalysts but face limitations like environmental sensitivity and instability.
• Metal-organic frameworks (MOFs) offer a promising solution to overcome these microbial limitations.

Purpose of the Study:

• To review recent advances and applications of synergistic systems between MOFs and microorganisms.
• To highlight the multifunctional roles of MOFs in microbial immobilization and metabolic regulation.

Main Methods:

• Comprehensive literature review of MOF-microorganism synergistic systems.
• Analysis of MOF properties (physical barriers, porosity, surface chemistry) for microbial enhancement.
• Examination of MOF-assisted cascade reaction systems.

Main Results:

• MOFs act as physical barriers, enhancing microbial cellular stability.
• Tunable MOF porosity and surface chemistry allow precise metabolic regulation.
• MOFs function as catalytic units in microbial cascade reaction systems.

Conclusions:

• MOF-microorganism interfaces and synthesis technologies are advancing rapidly.
• Rational design of MOF-based protective layers promises more efficient and stable microbial applications.
• This interdisciplinary field holds great potential for regulating biocatalytic processes in extreme industrial environments.