Total-Body PET in Theranostics: Reshaping Treatment Planning and Follow-Up

The advent of total-body PET/computed tomography (TB PET) is revolutionizing the field of molecular imaging. The high photon collection efficiency of TB PET translates into superior sensitivity and signal-to-noise ratio compared to conventional scanners, enabling shorter acquisition times and lower administered doses while significantly enhancing diagnostic performance. In the era of precision medicine, patient selection for radioligand therapy and treatment response assessment are expected to benefit from accurate lesion detection, dual-tracer studies, the use of short- and long-lived radiopharmaceuticals, tracer kinetic analysis, and frequent follow-up monitoring. These advantages are made possible by long-axial field-of-view scanners and further maximized through TB PET/CT.