Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mutations01:35

Mutations

45.7K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
45.7K
Mutations01:39

Mutations

98.0K
Overview
98.0K
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

294
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
294
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

8.9K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
8.9K
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

399
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
399
Obesity01:24

Obesity

1.6K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Estrogen receptor α (<i>Esr1</i>) mediates estrogen's ability to promote papillomavirus-induced cutaneous disease in male and female mice.

mBio·2026
Same author

Photophagy: Unveiling a Novel Cellular Mechanism in UVB-Induced Skin Aging and Resilience.

International journal of dermatology·2025
Same author

Integrating DNA damage response and autophagy signalling axis in ultraviolet-B induced skin photo-damage: a positive association in protecting cells against genotoxic stress.

RSC advances·2022
Same author

Inhibition of Ultraviolet-B Radiation Induced Photodamage by Trigonelline Through Modulation of Mitogen Activating Protein Kinases and Nuclear Factor-κB Signaling Axis in Skin.

Photochemistry and photobiology·2020

Related Experiment Video

Updated: Apr 10, 2026

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

2.2K

Beyond the Surface: Mechanistic Intersections Between Obesity and UVB Exposure.

Umar A Sheikh1,2,3, Tasduq A Sheikh4,5

  • 1McArdle Laboratory for Cancer Research, Department of Oncology, The School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. usheikh@wisc.edu.

International Journal of Obesity (2005)
|April 8, 2026
PubMed
Summary

Obesity and ultraviolet-B (UVB) radiation synergistically increase skin cancer risk by amplifying inflammation, oxidative stress, and impairing DNA repair and immune surveillance. Understanding these combined effects is crucial for integrated prevention strategies.

More Related Videos

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

18.9K
Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract
13:56

Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract

Published on: November 28, 2012

10.5K

Related Experiment Videos

Last Updated: Apr 10, 2026

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

2.2K
Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

18.9K
Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract
13:56

Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract

Published on: November 28, 2012

10.5K

Area of Science:

  • Dermatology and Oncology
  • Metabolic and Environmental Health
  • Immunology and Molecular Biology

Background:

  • Obesity and ultraviolet-B (UVB) radiation are independent risk factors for chronic diseases, including cancer.
  • Emerging evidence indicates mechanistic links between obesity and UVB exposure, potentially amplifying disease burden.
  • These factors converge on pathways like inflammation, oxidative stress, and immune dysregulation, particularly relevant to skin carcinogenesis.

Purpose of the Study:

  • To review the biological mechanisms linking obesity and UVB exposure.
  • To emphasize synergistic effects on oxidative stress, DNA repair (nucleotide excision repair), and immune surveillance.
  • To examine evidence and discuss therapeutic strategies for integrated prevention and risk management.

Main Methods:

  • Synthesis of recent experimental and clinical evidence on obesity and UVB interactions.
  • Analysis of overlapping pathways including inflammation, oxidative stress, DNA damage, and immune response.
  • Review of therapeutic strategies like vitamin D modulation and phototherapy.

Main Results:

  • Obesity and UVB exposure synergistically exacerbate oxidative stress and impair DNA repair efficiency.
  • Combined factors weaken immune surveillance and promote pro-tumorigenic microenvironments in the skin.
  • Shared pathways intensify oxidative injury, compromise DNA damage responses, and enhance skin cancer development.

Conclusions:

  • Obesity and UVB radiation act as a compound risk factor, significantly increasing skin cancer risk.
  • Integrated approaches targeting shared inflammatory, oxidative, and immune pathways are needed for prevention.
  • Therapeutic strategies like vitamin D modulation and phototherapy show promise in restoring immune balance and DNA repair.