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Updated: Apr 10, 2026

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Non-contact, Label-free Monitoring of Cells and Extracellular Matrix using Raman Spectroscopy
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Correction to "Detection of Inflammation in Vivo by Surface-Enhanced Raman Scattering Provides Higher Sensitivity
Analytical Chemistry
|April 9, 2026
Abstract
No abstract available in PubMed .
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The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
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A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
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The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
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