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An unrecognized non-pathologic filling defect on hysterosalpingography: A case report
Fereshteh Hosseini1, Fatemeh Safi2, Firoozeh Ahmadi1
1Department of Reproductive Imaging, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
International Journal of Reproductive Biomedicine
|April 9, 2026
Summary
Hysterosalpingography (HSG) can show filling defects, which are usually abnormal. This study highlights a rare normal variation that mimics pathology, emphasizing the need for careful interpretation in infertility evaluations.
Area of Science:
- Radiology
- Gynecology
- Infertility diagnostics
Background:
- Hysterosalpingography (HSG) is a key diagnostic tool for female infertility.
- Filling defects on HSG can indicate pathology (polyps, fibroids) or non-pathology (air, mucus).
- Understanding diverse HSG findings is crucial for accurate diagnosis.

