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Updated: Apr 10, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
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(E)-1-(3,3'-Dimeth-oxy-4'-{[(E)-4-nitro-benzyl-idene]amino}-[1,1'-biphen-yl]-4-yl)-N-(4-nitro-phen-yl)methanimine

Ouafa Boukhemis1, Ahlem Linda Boulkedid2, Mehdi Boutebdja3

  • 1National Biotechnology Research Center (CRBT), Industrial Biotechnology Division, Ali Mendjli New City, UV 03 BP E73, Constantine 25000, Algeria.

Iucrdata
|April 9, 2026
PubMed

Keywords:
Schiff basecrystal structure

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Primary, secondary, and tertiary amines are compounds consisting of one, two, and three alkyl groups connected to the amino group (–NH2), respectively. As depicted in Figure 1, the common name of the primary amines is obtained by adding the suffix -amine to the alkyl substituent attached to the amino group as the corresponding alkylamine.
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Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
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