Monosubstituted N-Arylhydroxylamine Chemistry: Integrating Contemporary Synthetic Approaches for the Efficient
Michael G Kallitsakis1, Kyriakos D Nikopoulos1, Ioannis N Lykakis1
1Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|April 9, 2026
Summary
N-arylhydroxylamines are versatile building blocks in organic synthesis. This review unifies synthetic strategies and applications, highlighting their role in creating complex heterocyclic architectures and valuable compounds.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
Background:
- Hydroxylamines are diverse compounds with varied reactivity.
- N-arylhydroxylamines are a unique subclass, crucial as intermediates in redox reactions and synthetic platforms.
Purpose of the Study:
- To present a unified perspective on synthetic approaches and applications of N-arylhydroxylamines.
- To emphasize the strategic importance of monosubstituted N-arylhydroxylamines.
- To provide a comprehensive review of their role in modern organic synthesis.
Main Methods:
- Review of recent advances in synthetic strategies for N-arylhydroxylamines.
- Analysis of practical applications of N-arylhydroxylamine motifs.
- Synthesis of complex heterocyclic architectures and organic compounds using N-arylhydroxylamines.
Main Results:
- N-arylhydroxylamines are key intermediates for diverse synthetic elaborations.
- Monosubstituted N-arylhydroxylamines are versatile building blocks.
- This class of compounds facilitates the construction of complex heterocyclic architectures.
Conclusions:
- N-arylhydroxylamines play a significant and versatile role in contemporary organic synthesis.
- Merging synthetic advances with applications reveals the strategic value of this compound class.
- Further exploration of N-arylhydroxylamine chemistry promises novel synthetic methodologies.
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