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Updated: Apr 10, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
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Published on: June 17, 2025

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Early-onset gestational pemphigoid in the first trimester: a diagnostic pitfall

Alessia Di Lorito1, Federica Giuliani2, Edvige Morea2

  • 1Pathology Department, SS Annunziata Hospital, Chieti, Italy.

Pathologica
|April 9, 2026
PubMed

This letter reports a case of a gestational pemphigoid (GP), a rare autoimmune subepidermal blistering disorder, typically arising in the third trimester of pregnancy. Early-onset presentations, during the first trimester, are exceptionally uncommon and may mimic other pregnancy-related dermatoses, delaying diagnosis. We report a rare early-onset case of GP and discuss the diagnostic challenges and management implications, allowing timely diagnosis and treatment, reducing maternal morbidity and potential obstetric complications.

Keywords:
autoimmune blistering diseasesdirect immunofluorescenceearly-onsetgestational pemphigoidpregnancy dermatoses

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