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Updated: Apr 10, 2026
Triplet Fusion Upconversion Nanocapsule Synthesis
Published on: September 7, 2022
Total Synthesis of Triplinone F
Manoj N Shet1,2, Krishna R Wabale1,2, Chepuri V Ramana1,2
1Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India.
None:
The first total synthesis of triplinone F, along with its C11 epimer, has been executed to establish, inter alia, the stereochemistry of C11 and its complete absolute configuration. The terminal styrene unit was added by cross-metathesis, whereby 1,3-diol units on either side of the central olefin were taken from malic acid enantiomers and coupled by a Yamaguchi alkyne-epoxide opening protocol. The C11 stereochemistry was manipulated by Noyori asymmetric ynone reduction. The Z-selective reduction of alkynoate and acid-catalyzed lactonization forged the right-hand-side 5,6-dihydro-δ-pyrone unit.
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