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Total Synthesis of Lucidimines/Ganocalicines A/B, Sinensine E, and Ganocochlearine E
Godi Kiran Venkata Sai1,2, Chepuri V Ramana1,2
1Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India.
Abstract:
The central tetracyclic framework shared by the Ganoderma alkaloids─lucidimines/ganocaclicines A and B, sinensine E, and ganocochlearine E─appears inherently predisposed to arise from a diyne-nitrile cyclotrimerization event. A Co(I)-catalyzed intramolecular [2 + 2 + 2]-alkynenitrile cyclotrimerization has been employed to accomplish the first racemic and enantioselective total syntheses of sinensine E, lucidimine A, and ganocochlearine E, thereby establishing/revising their assigned stereochemical structures.
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