DIA-PINN: A physics-informed machine learning method to estimate global intrinsic diastolic chamber properties of the...

Pressure-volume (PV) loop analysis remains the gold standard for assessing the intrinsic global diastolic properties of the left ventricle (LV). Traditional fitting techniques rely on local, phase-constrained fittings and are limited due to their sensitivity to noise, landmark selection, violation of assumptions, and nonconvergence. We aimed to develop and validate DIA-, a physics-informed neural network (PINN) framework capable of calculating intrinsic diastolic properties of the LV from measured instantaneous PV data, combining mechanistic interpretability with machine learning flexibility. Instantaneous LV diastolic pressure was modeled as the sum of 1) time-dependent relaxation-related pressure and 2) volume-dependent recoil and stiffness-related pressures. DIA-PINN was trained using time, LV pressure, and LV volume as inputs, enforcing data fidelity, model consistency, and physiological plausibility within the loss function. Performance was evaluated in 4,000 Monte Carlo simulations of LV PV-loops, and in clinical data from 59 patients who underwent catheterization (39 with heart failure and normal ejection fraction and 20 controls). DIA-PINN-derived indices were compared with those obtained from a previously validated global optimization method (GOM). On the simulation data, DIA-PINN accurately recovered all constitutive indices (intraclass correlation coefficients near unity) and improved GOM performance. On the clinical data, diastolic indices derived using DIA-PINN strongly correlated with GOM estimates (R > 0.90, P < 0.001) but were insensitive to initialization. DIA-PINN performed best under vena cava occlusion, as varying preload improved parameter identifiability. When applied to instantaneous pressure-volume data, a generalizable PINN framework, DIA-PINN, provides an improved method for assessing global intrinsic diastolic properties of cardiac chambers.NEW & NOTEWORTHY Our work introduces DIA-PINN, a physics-informed neural network framework to process instantaneous ventricular pressure-volume data, solving a mechanistic model of diastole with machine learning techniques. Compared with current conventional or optimization-based approaches, the PINN provides the most reliable estimates of diastolic stiffness, relaxation, and elastic recoil, insensitive to initialization. By embedding physiological constraints into network training, this approach achieves robust, interpretable, and clinically applicable quantification of gold-standard metrics of intrinsic global diastolic chamber properties.